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PGPB are able to control the number of pathogenic bacteria through microbial antagonism, competing for nutrients, producing antibiotics, and anti-fungal metabolites. Rhizobacteria Induced systemic resistance (ISR) triggers a reaction in the roots that creates a signal that spreads throughout the plant which results in the activation of defense mechanisms, such as, reinforcement of plant cell wall, production of anti-microbial phytoalexins, and the synthesis of pathogen related proteins.